Ceded in 1504 by the Friars Minor to Consalvo de Cordovathe first viceroy of Naples, who made it his aristocratic chapel. The chapel was rebuilt in 1634-1646 under the direction of Cosimo FANZAGO.
In the vault:
- Massimo STANZIONE (1585-1656), frescoes with Stories from the Life of St James of the Marches and Virtues (1644-1646).
At the base of the major arch:
- Annibale CACCAVELLO (1515-1570), tomb monuments of Odetto de Foix and Pietro Navarro.
Chapel - La Purità
In the vault:
- Giacinto DE POPULI (news 1650-1682), frescoes with Assumption, Annunciation and Joseph's Dream.
On the altar and walls:
- Francesco DE MARIA (1623-1690), Our Lady of Purity, Visitation and Rest on the Flight into Egypt.
Chapel - St. John the Baptist - (Parisio family)
On the altar:
- Pietro BERNINI (1565-1629), St John the Baptist.
In the vault:
- Luca GIORDANO (1632-1705), frescoes with Stories of the Baptist.
Chapel - S. Diego d'Alcalà - (D'Aquino family of the Dukes of Casola)
- Cosimo FANZAGO (1591-1678), statues of St Thomas and St Andrew, tomb monuments of the d'Aquino family
On the altar:
- Joseph RIBERA (1591-1652), San Diego.
In the vault:
- Massimo STANZIONE (1585-1656), frescoes with Stories of San Diego d'Alcalá.
Chapel - Immaculate - (Turbolo family)
On the altar:
- Girolamo D'AURIA, Immaculata, St Francis and St Bernardino (1590-1600).
- Bernardo SICILIANO or Silvestro MORVILLO, frescoes with Stories of the Virgin.
Chapel - Nativity of Jesus Christ - (De Rosa family)
On the altar:
- Leonardo BASSANO (1557-1622), Nativity.
On the left wall:
- Giovanni BALDUCCI (news 1575-1631), Birth of the Virgin.
On the right wall:
- Donzelli School, Adoration of the Magi.
In the vault:
- Massimo Stanzione School, frescoes with Massacre of the Innocents, Announcement to the Shepherds, Flight into Egypt.
VI altar - Holy Saviour:
- Girolamo IMPARATO (news 1571-1607), Salvator Mundi.
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